Office of Environmental Health Hazard Assessment
Prop 65 Implementation
PO Box 4010
1
Office of Environmental Health Hazard Assessment
Prop 65 Implementation
PO Box 4010
1001 I St., 19th Floor
Sacramento CA 95812-4010 We are responding to OEHHA's request for scientific information regarding the carcinogenicity of marijuana smoke for hearings by the Carcinogen Identification Committee on November 19, 2007. The best current evidence is that marijuana smoke does not cause cancer. Even though it can contain various carcinogenic pyrolytic compounds similar to those found in tobacco smoke, the best epidemiological studies have failed to detect elevated cancer rates in marijuana smokers. One possible explanation is that the major psychoactive ingredient of marijuana, delta-9-tetrahydrocannabinol (THC) has anti-carcinogenic properties, whereas the major ingredient of tobacco, nicotine, is cancer promoting [Melamede[1]].
http://www.canorml.org/healthfacts/OEHHA_Prop_65_MJ_Canc.htm
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Click here for more details and links to text in original form.
http://www.norml.org/index.cfm?Group_ID=7121
Multiple Sclerosis
Clinical and anecdotal reports of cannabinoids' ability to reduce MS-related symptoms such as pain, spasticity, depression, fatigue, and incontinence are plentiful in the scientific literature[1-12] — leading many MS-associated patient organizations, including the Multiple Sclerosis Societies of Britain and Canada, to take positions in favor of the drug's prescription use.[13] Patients with multiple sclerosis typically report engaging in cannabis therapy[14], with one survey indicating that nearly one in two MS patients use the drug therapeutically.[15]
Recent clinical and preclinical studies also suggest that cannabinoids may inhibit MS progression. Writing in the July 2003 issue of the journal Brain, investigators at the University College of London's Institute of Neurology reported that administration of the synthetic cannabinoid agonist WIN 55,212-2 provided "significant neuroprotection" in an animal model of multiple sclerosis. "The results of this study are important because they suggest that in addition to symptom management, ... cannabis may also slow the neurodegenerative processes that ultimately lead to chronic disability in multiple sclerosis and probably other disease," researchers concluded.
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The Author at the Norml Library:
(link to original text location)
http://norml.com/index.cfm?Group_ID=7002
For patients and their physicians, let this report serve as a primer for those who are considering using or recommending medicinal cannabis. For others, let this report serve as an introduction to the broad range of emerging clinical applications for cannabis and its various compounds.
Paul Armentano
Deputy Director
NORML | NORML Foundation
Washington, DC
January 24, 2008
* The author would like to acknowledge Drs. Dale Gieringer, Gregory Carter, Steven Karch, and Mitch Earleywine, as well as NORML interns John Lucy, Christopher Rasmussen, and Rita Bowles, for providing research assistance for this report. The NORML Foundation would also like to acknowledge Dale Gieringer, Paul Kuhn, and Richard Wolfe for their financial contributions toward the publication of this report.
** Important and timely publications such as this are only made possible when concerned citizens become involved with NORML. For more information on joining NORML or making a donation, please visit: http://www.norml.org/join. Tax deductible donations in support of NORML's public education campaigns should be made payable to the NORML Foundation.
________________________________________
Placed by the Channel owner:
"Prohibition...goes beyond the bounds of reason in that it attempts to control a man's appetite by legislation and makes a crime out of things that are not crimes. A prohibition law strikes a blow at the very principles upon which our government was founded." -- Abraham Lincoln December 1840
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Madrid, Spain: Compounds in marijuana inhibit malignant brain tumor growth in animals, and
Madrid, Spain: Compounds in marijuana inhibit malignant brain tumor growth in animals, and may provide a potential therapy for human glioma patients, according to a clinical review appearing in the September issue of Neuropharmacology.
"Current therapeutic strategies for the treatment of [gliomas] are usually ineffective or just palliative," researchers from the Department of Biochemistry and Molecular Biology at Madrid's Complutense University wrote. "During the last few years, several studies have shown that cannabinoids ... slow the growth of different types of tumours, including gliomas, in laboratory animals. Cannabinoids induce apoptosis (programmed cell death) of glioma cells [in vitro.] In addition, cannabinoid treatment inhibits angiogenesis (growth) of gliomas in vivo. Remarkably, cannabinoids kill glioma cells selectively and can protect non-transformed glial cells from death. These and other findings reviewed here might set the basis for a potential use of cannabinoids in the management of gliomas."
Last year, a clinical review in the journal Nature Reviews Cancer made similar recommendations, noting that cannabinoids possess a "favorable drug safety profile" and have shown in clinical trials to inhibit various forms of cancerous tumors, including gliomas, lung carcinoma, breast cancer, skin cancer, thyroid cancer, lymphoma, and prostate cancer.
For more information, please contact Paul Armentano, NORML Senior Policy Analyst, at (202) 483-5500. Abstracts of the review are available online at:
http://else.hebis.de/cgi-bin/sciserv.pl?collection=journals& journal=00283908
The author
For patients and their physicians, let this report serve as a primer for those who are considering using or recommending medicinal cannabis. For others, let this report serve as an introduction to the broad range of emerging clinical applications for cannabis and its various compounds.
Paul Armentano
Deputy Director
NORML | NORML Foundation
Washington, DC
January 24, 2008
* The author would like to acknowledge Drs. Dale Gieringer, Gregory Carter, Steven Karch, and Mitch Earleywine, as well as NORML interns John Lucy, Christopher Rasmussen, and Rita Bowles, for providing research assistance for this report. The NORML Foundation would also like to acknowledge Dale Gieringer, Paul Kuhn, and Richard Wolfe for their financial contributions toward the publication of this report.
** Important and timely publications such as this are only made possible when concerned citizens become involved with NORML. For more information on joining NORML or making a donation, please visit: http://www.norml.org/join. Tax deductible donations in support of NORML's public education campaigns should be made payable to the NORML Foundation.
http://norml.com/index.cfm?Group_ID=7002
_______________________________________
"Prohibition...goes beyond the bounds of reason in that it attempts to control a man's appetite by legislation and makes a crime out of things that are not crimes. A prohibition law strikes a blow at the very principles upon which our government was founded." -- Abraham Lincoln December 1840
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background music,
http://www.soundsnap.com
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The FDA on Viagra
The FDA on Pot
The FDA passed Viagra in a few years but still claims
The FDA on Viagra
The FDA on Pot
The FDA passed Viagra in a few years but still claims it has to study Marijuana even though they US Government has prescribed it for a small group of Americans (was 12 now 8 people) as far back as the 1960's.
Viagra passed in less than 10 years but 50 years later they claim they still need to study Marijuana.
Those who get it from the US Government have never been studied by the FDA or anyone related to the government. A few of them paid for their own medical study and were found to be in excellent shape. Even those who had smoked Pot daily for 30 years were NOT showing negative effects worth a medical note.
Yet my state of NC has Richard Burr claiming they need to study it. FINE, THEN STUDY IT AND STOP LYING. You go ahead and get a hard on while people suffer. I hope the sex and possible blindness from Viagra is worth making others suffer Mr Burr. Notice I don't use his title and I won't. The very idea that this man has any say over my states health issues scares me. HIs office can't even send proper reply if you email them on the subject. They sent me a reply that had nothing to do with the subject. If they cannot keep their communications straight, I dare to say they can't keep our needs straight either! That IS my OPINION.
Does anyone really think it takes 50 years to study a natural compound? Anyone with any logic buy that crap?
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visit http://www.norml.com
Notice the list for Side Effects of Marijuana is 1 slide/p
visit http://www.norml.com
Notice the list for Side Effects of Marijuana is 1 slide/page and mentions 'naive users'.
Then notice on prescription drug side effects, a random sampling of the side effects associated with numerous prescriptions that are used by drug companies to replace the 'demon weed'...well that list of side effects goes on and on...
Nuf Said Yet?
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Prescription drugs kill millions and Marijuana kills no one. But one is legal to kill you
Prescription drugs kill millions and Marijuana kills no one. But one is legal to kill you and the other is illegal even if it can keep you alive!
Marijuana CAN kill certain Cancers including Gliomas. It is natures Antineoplastic.
Synthetic Antineoplastics cause many horrible side effects but Marijuana does not.
Do you want to get sicker? Or do you want to get better? Do you want the Drug Companies to keep putting toxins in your body or do you want to use what God put on this earth?
Your call! End Prohibition now.
"Prohibition...goes beyond the bounds of reason in that it attempts to control a man's appetite by legislation and makes a crime out of things that are not crimes. A prohibition law strikes a blow at the very principles upon which our government was founded." -- Abraham Lincoln December 1840
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Added: 4 months ago
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Glioma Research (click more for details)
A review of the modern scientific literature r
Glioma Research (click more for details)
A review of the modern scientific literature reveals numerous preclinical studies and one pilot clinical study demonstrating cannabinoids' ability to act as antineoplastic agents, particularly on glioma cell lines.
Writing in the September 1998 issue of the journal FEBS Letters, investigators at Madrid's Complutense University, School of Biology, first reported that delta-9-THC induced apoptosis (programmed cell death) in glioma cells in culture.[1] Investigators followed up their initial findings in 2000, reporting that the administration of both THC and the synthetic cannabinoid agonist WIN 55,212-2 "induced a considerable regression of malignant gliomas" in animals.[2] Researchers again confirmed cannabinoids' ability to inhibit tumor growth in animals in 2003.[3]
That same year, Italian investigators at the University of Milan, Department of Pharmacology, Chemotherapy and Toxicology, reported that the non-psychoactive cannabinoid, cannabidiol (CBD), inhibited the growth of various human glioma cell lines in vivo and in vitro in a dose dependent manner. Writing in the November 2003 issue of the Journal of Pharmacology and Experimental Therapeutics Fast Forward, researchers concluded, "Non-psychoactive CBD ... produce[s] a significant anti-tumor activity both in vitro and in vivo, thus suggesting a possible application of CBD as an antineoplastic agent."[4]
To see this text in full:
http://www.norml.org/index.cfm?Group_ID=7008
_______________
The Author:
For patients and their physicians, let this report serve as a primer for those who are considering using or recommending medicinal cannabis. For others, let this report serve as an introduction to the broad range of emerging clinical applications for cannabis and its various compounds.
Paul Armentano
Deputy Director
NORML | NORML Foundation
Washington, DC
January 24, 2008
* The author would like to acknowledge Drs. Dale Gieringer, Gregory Carter, Steven Karch, and Mitch Earleywine, as well as NORML interns John Lucy, Christopher Rasmussen, and Rita Bowles, for providing research assistance for this report. The NORML Foundation would also like to acknowledge Dale Gieringer, Paul Kuhn, and Richard Wolfe for their financial contributions toward the publication of this report.
** Important and timely publications such as this are only made possible when concerned citizens become involved with NORML. For more information on joining NORML or making a donation, please visit: http://www.norml.org/join. Tax deductible donations in support of NORML's public education campaigns should be made payable to the NORML Foundation.
http://norml.com/index.cfm?Group_ID=7002
_______________________________________
Prohibition:
"Prohibition...goes beyond the bounds of reason in that it attempts to control a man's appetite by legislation and makes a crime out of things that are not crimes. A prohibition law strikes a blow at the very principles upon which our government was founded." -- Abraham Lincoln December 1840
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Added: 4 months ago
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Incontinence Research (click more for details)
Several recent clinical trials indicate th
Incontinence Research (click more for details)
Several recent clinical trials indicate that cannabinoid therapy may reduce incidents of incontinence. Writing in the February 2003 issue of the journal Clinical Rehabilitation, investigators at Oxford's Centre for Enablement in Britain reported that self-administered doses of whole-plant cannabinoid extracts improved bladder control compared to placebo in patients suffering from MS and spinal cord injury.[1]
Investigators at London's Institute for Neurology followed up these initial findings in an open-label pilot study of cannabis-based extracts for bladder dysfunction in 15 patients with advanced multiple sclerosis. Following cannabinoid therapy, "urinary urgency, the number of and volume of incontinence episodes, frequency and nocturia all decreased significantly," investigators determined. "Cannabis-based medicinal extracts are a safe and effective treatment for urinary and other problems in patients with advanced MS."[2]
The full text:
http://www.norml.org/index.cfm?Group_ID=7012
___________________________________________
The Author:
For patients and their physicians, let this report serve as a primer for those who are considering using or recommending medicinal cannabis. For others, let this report serve as an introduction to the broad range of emerging clinical applications for cannabis and its various compounds.
Paul Armentano
Deputy Director
NORML | NORML Foundation
Washington, DC
January 24, 2008
* The author would like to acknowledge Drs. Dale Gieringer, Gregory Carter, Steven Karch, and Mitch Earleywine, as well as NORML interns John Lucy, Christopher Rasmussen, and Rita Bowles, for providing research assistance for this report. The NORML Foundation would also like to acknowledge Dale Gieringer, Paul Kuhn, and Richard Wolfe for their financial contributions toward the publication of this report.
** Important and timely publications such as this are only made possible when concerned citizens become involved with NORML. For more information on joining NORML or making a donation, please visit: http://www.norml.org/join. Tax deductible donations in support of NORML's public education campaigns should be made payable to the NORML Foundation.
http://norml.com/index.cfm?Group_ID=7002
____________________________________________________________ ___
"Prohibition...goes beyond the bounds of reason in that it attempts to control a man's appetite by legislation and makes a crime out of things that are not crimes. A prohibition law strikes a blow at the very principles upon which our government was founded." -- Abraham Lincoln December 1840
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Added: 4 months ago
Views: 434
Pruritus Research (click more for details)
A review of the scientific literature reveal
Pruritus Research (click more for details)
A review of the scientific literature reveals three clinical trials investigating the use of cannabinoids in the treatment of pruritus. Writing in the August 2002 issue of the American Journal of Gastroentrology, investigators from the University of Miami Department of Medicine reported successful treatment of pruritus with 5 mg of THC in three patients with cholestatic liver disease.[1] Prior to cannabinoid therapy, subjects had failed to respond to standard medications and had lost their ability to work. Following evening cannabinoid administration, all three patients reported a decrease in pruritus, as well as "marked improvement" in sleep and were eventually able to return to work. Resolution of depression was also reported in two out of three subjects. "Delta-9-tetrahydrocannabinol may be an effective alternative in patients with intractable cholestatic pruritus," investigators concluded.
The following year, British researchers reported in the June 2003 issue of the journal Inflammation Research that the peripheral administration of the synthetic cannabinoid agonist HU-211 significantly reduced experimentally-induced itch in 12 subjects.[2] Investigators had previously reported that topical application of HU-210 on human skin reduced experimentally-induced pain and acute burning sensations.[3]
Full text link:
http://www.norml.org/index.cfm?Group_ID=7014
The authour:
For patients and their physicians, let this report serve as a primer for those who are considering using or recommending medicinal cannabis. For others, let this report serve as an introduction to the broad range of emerging clinical applications for cannabis and its various compounds.
Paul Armentano
Deputy Director
NORML | NORML Foundation
Washington, DC
January 24, 2008
* The author would like to acknowledge Drs. Dale Gieringer, Gregory Carter, Steven Karch, and Mitch Earleywine, as well as NORML interns John Lucy, Christopher Rasmussen, and Rita Bowles, for providing research assistance for this report. The NORML Foundation would also like to acknowledge Dale Gieringer, Paul Kuhn, and Richard Wolfe for their financial contributions toward the publication of this report.
** Important and timely publications such as this are only made possible when concerned citizens become involved with NORML. For more information on joining NORML or making a donation, please visit: http://www.norml.org/join. Tax deductible donations in support of NORML's public education campaigns should be made payable to the NORML Foundation.
http://norml.com/index.cfm?Group_ID=7002
_______________________________________
Prohibition:
"Prohibition...goes beyond the bounds of reason in that it attempts to control a man's appetite by legislation and makes a crime out of things that are not crimes. A prohibition law strikes a blow at the very principles upon which our government was founded." -- Abraham Lincoln December 1840
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